PERSANTINE
CONTRAINDICATIONS:
                                -Asthma with ongoing wheezing
                                -AVB 2nd or 3rd degree
(without PM)
                                
-SSS (without PM)
                                
-SBP < 90 mmHg
                                -Recent use of Dipyridamole
or dipyridamole containing drigs (Aggrenox)
                                
-Methyl Xanthines (aminophylline, caffeine, theobromine) block the effect
                                of adenosine and should be held at least 12 hours
                                
-Hypersensitivity to Adenosine
                                -Unstable acute MI or ACS
                                -Profound Bradycardia (< 40 bpm)

STOPPING
                                 -Hypotension (SBP<80 mmHg)
                                 -Symptomatic, persistent 2nd or 3rd AVB
                                 -Wheezing
                                 -Chest pain with >2 mm ST depressions
                                 -Signs of poor perfusion (pallor, cyanosis, cold skin)
                                 -Patient's request
                          
Mechanism of action indirect coronary artery vasodilator that increases tissue levels of adenosine
by
preventing the intracellular reuptake and deamination of adenosine. Dipyridamole induced
hyperemia lasts
> 15 min.

Side Effects
-50% of patients develop side effects: flushing, chest pain, headache, dizziness, hypotension)
-Frequency of side effects less than adenosine but last longer (15-25 min)
-AVB less than adenosine (<2%)
-Modest increase in HR and decrease in BO

Dosage 0.56 mg/kg IV over a 4 minute period (142 mcg/kg/min) - Half-Life is 30-45 '
PERSANTINE
RADIOTRACER
3-5'
0.56 mg/Kg - 4' by hand injection
followed by NS flush
1.7 mph, 0% grade exercise
6'
6' after completion of
the infusion
AMINOPHYLLINE        125 to 250 mg by slow IV injection (30-60 seconds)
4'

1.7 mph, 0% grade exercise decreases Adenosine side effects and hypotension
Not recommended for patients with LBBB